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NanoBioMedicine 6 Volumes Set

Author Name : Bhupinder Singh


  • Publisher : Studium Press LLC
  • Edition : 1st
  • ISBN 10 : 1-626990-50-6
  • Page no : 3007
  • Publication Year : 2015

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  • Description
  • Table Of Content
  • Reviews
We are amidst a nanotechnology era. The word, “nano”, worth one-billionth (of a meter), has attained mega proportions, worth billions (of USD). Virtually, nothing remains to be nanonized at the moment, whatever may be the domain. Traversing a voyage from the origin of its idea by Richard Feynman in 1959, nanotechnology has entered into our “present” living, society and culture to shape our “future”. Knowledge and knowhow to engineer and manufacture the nanoscaled products have practically unleashed a revolution, creating waves all across the scientific disciplines and industrial sectors. Amongst the most promising benefits of nanotechnology galore, its applications in health care are considered as paramount. This perspective assumes immense significance, as the whole world is experiencing unprecedented medical challenges and changes in relation to diseases, diagnosis and drugs. Robert Freitas, in his book on ‘Nanomedicine’ in 1999, presented the first detailed discussion on the medical applications of nanotechnology, predicting its brilliant capabilities in future. It is no surprise that Nanomedicine is the fastest emerging offshoot of nanotechnology. Further integration of Nanomedicine with biological sciences, like biotechnology, biochemistry, pharmaceutical sciences, biomedical engineering, bioimaging, nanomedical robotics and biomedical technology, has spurred the genesis of a whole new field of “NanoBioMedicine”. Founded on the premise of monitoring, repairing, constructing and controlling human biological systems at molecular level, employing various nanostructures and nanodevices, Nanobiomedicine primarily endeavors to improve upon the patient safety, efficacy, economy, and compliance of varied therapeutic, preventive and diagnostic strategies. Not merely dealing with the nuances of interactions of nanostructures with biomolecular receptors, the contemporary discipline of Nanobiomedicine also embraces the methods of design, engineering and technological transfer of nanostructured materials for delivery of drugs and biomacromolecules, and fabrication of cutting-edge biomedical devices. Drawing apt inputs from almost all the frontiers of science and technology, Nanobiomedicine today is heralding a new epoch in medicare with lots of hopes and promises for the suffering society. Nanobiomedicine these days has been making strides at a striking pace, eventually providing significant impetus towards scientific enthusiasm, research efforts, industrial anticipation, and regulatory attention. Of late, several nanostructured drug delivery products have been introduced in the commercial circulation, with thousands more in the pipeline and yet more in the early stages of developmental research. A huge proportion of these innovative nanoscaled products have demonstrated enormous patient benefits and, in several cases, solutions to previously unsurmountable medical problems. In the coming decade, Nanobiomedicine is further anticipated to radically impact almost all the terrains of patient care, clinical and veterinary practice, medical biotechnology and above all, the pharmaceutical market. Some analysts are even prophesising the global sales of these innovative and therapeutically superior nanotech-enabled medicinal products to cross $200 billion mark in the next decade. The acute need of the current hour, accordingly, is to acquaint the professionals with advances in this vibrant science of exponentially growing importance. A recent literature survey of the leading journals revealed phenomenally high rate of publications in this multi- and interdisciplinary domain of Nanobiomedicine. Verily, the “half-life”of information in the realm has been declkining quite rapidly. For a field advancing as fast as this one, it is quite challenging to obtain a complete overview of the dynamic developments, as most updated information on such nano-bio interfaces lies scattered in diverse journals. Owing to the nonavailability of the standard treatise(s) on the subject, we have undertaken this maiden but humble endeavour to present the pertinent facts and figures in the form of a comprehensive multi-volume series on Nanobiomedicine. The book series, currently a collection of six volumes, endeavors to cover a gamut of novel and evolving subject topics spanning Nanobiomedicine. Each individual volume is an assortment of choicest reviews and research articles contributed by distinguished scientists and leading experts in the field. The compendium aspires to provide a high quality insight into most of the pertinent aspects of Nanobiomedicine including nano-based drug delivery systems, multifunctional theranostic agents, nanopharmaceuticals, functionalized therapeutic nanocarriers, and myriad nanobiotechnological approaches. The primary motivation behind this Herculean effort has been to present the latest research in the field as gathered from the eminent scientists across the world in the form of a multi-volume digest. The book series comprises of six volumes, viz. Volume 1: Nanomedicine Volume 2: Nanopharmaceuticals Volume 3: Nanotheranostics Volume 4: Nanostructured Drug Delivery Volume 5: Medical Nanobiotechnology Volume 6: Drug Nanocarriers Nanomedicine, the first volume of the series, sets the stage by providing an overview of the current status of the field. The volume introduces and highlights the cornerstone research accomplishments that are already creating or promising to create profound impact in improving treatment of several diseases such as cancer, bacterial infections, coronary heart diseases, arthritis and ocular diseases. Various medically employed nanostructures and their properties, design principles, applications, toxicological challenges and safety issues are thoroughly reviewed. Emerging concept of the use of prodrugs, nanochiral drugs, drug eluting stents, implants and novel nanotechnology-enabled tools for enhancing drug penetration and drug bioavailability have also been put forth in a scrupulous manner. Endeavored towards creating an understanding and appreciation of the struggle and challenges involved in commercializing the nanoproducts for humans, the second volume of this series embraces the topic of Nanopharmaceuticals, the pharmaceutical dosage forms produced using nanotechnology. The book enlightens the systematic use of multivariate techniques and physiology-based pharmacokinetic modeling to design and develop novel nanopharmaceutical formulations. It also accentuates the concept of chronopharmacokinetics, a consideration that should be taken into account for developing chronotherapeutic nanopharmaceuticals. Apart from a thorough overview of advancements in nanopharmaceuticals for parenteral, transmucosal and oral delivery, the book volume furnishes a lucid account of scalability issues and the role of pilot plant studies in process scale-up, which is absolutely indispensable for large scale manufacturing of nanopharmaceuticals. Endowing with the ability to move one step closer to realizing the true potential of Nanobiomedicine is the realm of nanotheranostics, i.e., maneuvering therapeutics and diagnostics into a single platform. The rudiments and recent advances in Nanotheranostics have been exclusively dwelt in the third volume of the series. The book mainly deals with the state-of-art developments in promising nanostructured carriers including metallic nanoparticles, semiconductor nanoparticles, radiolabelled nanoparticles, mesoporous silica nanoparticles and gold nanorods. Due to their distinguished surface chemistries and unique optical and electrical properties, they are capable of combining drug delivery and multimodal imaging, thus, enabling image-guided therapies and ultimately rendering the therapeutics highly personalized. Volume four is a testament to the colossal progress made in the field of Nanostructured Drug Delivery, a domain of Nanobiomedicine that has received the greatest impetus and focus so far. The book begins with a detailed account on how Quality by Design principles can be systematically drawn on to design novel nanostructures for improved drug delivery. The book then gives an overview of several nanostructures for improving the delivery of BCS Class III drugs, genes, proteins and peptides. The work presented in the book provides tangible documentary evidence as to how innovations in nanostructured drug delivery hold significant promise in overcoming inadequacies of conventional drug delivery systems, particularly in dodging resistance during the treatment of cancer and multi-drug resistant tuberculosis. Towards the end, the book draws attention towards a very vital aspect of nanostructures–safety and toxicological assessment. Placing the federal regulations in position to ensure the safety of nanostructures will pave the way for bringing these nanostructures from bench to bedside. Highly unconventional and sophisticated medical applications of nanotechnology, which are though still in their infancy but hold immense prospects in fostering human health care, are propounded in the fifth volume “Medical Nanobiotechnology.” Using virus and nanosized viral scaffolds as drug delivery vehicles or developing a nanoparticle-based customized tissue-engineered implant for peripheral nerve reconstruction could not have been even envisaged a few years ago, but represent realms being pursued with great enthusiasm today. The book brings the lesser known facets of nanotechnology applications like formulation and targeted delivery of small interfering RNA, mitochondrial targeting of drugs, and fabricating nanocrystalline bioactive coatings for implants to the surface for open debate. Discovery and development of an improved drug is a time-consuming and expensive endeavor, associated with a towering failure rate. Creating new garbs for existing drugs has enormous potential to overcome their erstwhile limitations including low solubility, low biological availability, non-specific biodistribution and toxicity. Drug Nanocarriers, the most powerful weapon in the repertoire of nanomedicine armor, is therefore, the subject of discussion of the final and sixth volume of the series. The book successfully describes self-emulsifying drug delivery systems, ethosomes, dendrimers, herbosomes, organogels, nanoparticles, injectable delivery forms, nanoplexes and other novel drug carriers. The applications and scope of these delivery systems in topical, transdermal, intranasal, and ocular as well as cell and organelle-specific drug delivery are also presented. Evidently, all these volumes put together underscore some of the most remarkable advances that have taken place recently in the vast field of Nanobiomedicine, and reflect new challenges and issues confronting their further progress. The series seeks to offer the readers a rich tête-à-tête with fresh and original perspectives mirroring a diversity of experience, wisdom and vision, which is quite implausible to be made available collectively anywhere else. I am quite fascinated and satiated that the long-felt void of a repository on the much sought-after discipline of Nanobiomedicine is being filled up through this current multi-volume book series. Verily, it is like a cherished dream coming true to bring forth this repertoire, intended to be a classic for the current and future generations to come. The contents of the book series, contributed by scientists with different expertise, have been meticulously customized to steer the aspirants and enthusiasts on recent and upcoming nanotechnology-related trends, especially in the fields of diagnostics, prophylactics, therapeutics, drug delivery, pathology, biotechnology, pharmacogenomics, human gene biology, clinical pharmacology, and so on. At this juncture, I would like to take this opportunity to thank many people whose pooled efforts brought this mega series into real being. The list includes all the authors, editorial board members, the team of publishing house, my research group, and several others. First and the foremost, I express my heartfelt gratitude to the eminent and erudite authors for adroitly working on the chapters by compiling most comprehensive and updated information on wide-ranging subject(s). Not only these contributors met the stringent timelines, they also complied with a variety of editorial suggestions sportingly. They garnished and flavoured these chapters with suitable perspectives, usually emanating from their own experience and expertise. Based on the famous adage, ‘A picture is worth a thousand words’, earnest efforts have been made by the articulate authors to encompass a diversity of graphic illustrations of various works, presented immaculately as explicative graphs, photographs, methodology flow charts, apparatus outlines, tables, bar charts, etc. Each chapter has been duly referenced to current literature, invariably citing vital texts for further reading too. As the Editor-in-Chief of the book series, I fall short of apt words to express my deep appreciation and acknowledgment to the eloquent editors of the six volumes for pouring in their invaluable and pertinent inputs from time-to-time. The sagacious, prompt and critical feedback provided by them helped in ameliorating the quality of the manuscripts a great deal. All the editors further put across their gratefulness to the learned Editorial Board Members and worthy reviewers of the individual chapters in spending a lot of their priceless time to ensure high standards of the book. We put into record the highly painstaking, persistent and meticulous efforts of the management and staff members of the publisher, viz., M/S Studium Press LLC, USA, in bringing out this mega compilation. Without their immense support and direction, it could not have been possible to make this colossal series a reality in a timely manner. Our well-knit team of extremely diligent, systematic and perseverant researchers and post-docs deserve the exceptional mention, as they were the spinal column of this massive and momentous project. Naming a few while leaving many others may only demean their wonderful contribution for which I would always remain beholden. I take this opportunity of acknowledging the University Grants Commission (UGC), New Delhi, India, for having chosen the Panjab University, Chandigarh, for awarding this prestigious UGC Centre of Excellence in “Applications of Nanomaterials, Nanoparticles & Nanocomposites” with focus area of Biomedical Sciences. Verily, the drive to take up this marathon task for writing the book was initiated after my assuming the charge of this Centre of Excellence, dedicated to explore and establish various Nanobiomedicine precepts. Thanks are also due to the financial support provided by various other gubernatorial agencies like Council of Scientific and Industrial Research (CSIR), Indian Council of Medical Research (ICMR), Department of Science and Technology (DST), Department of Biotechnology (DBT), and All India Council of Technical Education (AICTE) to enable us to bring out tangible outcomes on nanostructured systems. Several of such works on nanopatterned structures, primarily employing QbD-based paradigms, have fetched exalted global recognitions including by American Association of Pharmaceutical Sciences (USA), Select Biosciences (UK), StateEase Inc. (USA), CPhI-Asia, and APTI (India). Tangible financial support received from Pharma industrial houses is also gratefully appreciated for developing diverse innovative nanostructured systems and characterizing them. Let me now invite you to begin this voyage to “Nanobiomedicine,” - a mission with the message, “Think Small and Change Lives in a Big Way.” I sincerely wish, hope and pray that the current six-volume book series on Nanobiomedicine will serve the unmet needs of the scientists and practitioners to harvest its stellar benefits.
Title NanoBioMedicine 6 Volumes Set
Table of Content Please see the Table of Contents in respective vols.
Page No. 3007
Author's Name Bhupinder Singh
Publisher Studium Press LLC
Year Of Publication 2015
ISBN 10 1-626990-50-6
ISBN 13 No
About The Book No
Binding type No
Book Size(len) No
Series Series
book size(hei) N/A
Book size width N/A
Edition 1st

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